Adventures in time and space
نویسندگان
چکیده
منابع مشابه
Adventures in time and space
C of pre-mRNA splicing is a critical part of the eukaryotic gene expression process. Extensive evidence indicates that transcription and splicing are spatiotemporally coordinated and that most splicing events occur co-transcriptionally. A kinetic coupling model has been proposed in metazoans to describe how changing RNA Polymerase II (RNAPII) elongation rate can impact which alternative splice ...
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It has been a long-held assumption in ligand-based virtual screening that the bioactive conformation of a molecule is privileged. The assumption is that superior performance in 3D searching (pharmacophores, shape similarity) should be obtained when using the bioactive conformation of a query molecule for searching for other active molecules. A parallel assumption has been that extensive samplin...
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This is my contribution to the Festschrift honoring Stephen Hawking on his 60th birthday. Twentyfive years ago, Gibbons and Hawking laid out the semi-classical properties of de Sitter space. After a summary of their main results, I discuss some further quantum aspects that have since been understood. The largest de Sitter black hole displays an intriguing pattern of instabilities, which can ren...
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We report on the progress of a constructive mechanization for a small subset of signal processing theory, built upon the SSREFLECT and MATHCOMP libraries. The development was started to provide mechanized semantics for audio programming languages. Currently, we have formalized several standard properties of the Discrete Fourier Transform, such as its unitary matrix form and its power and convol...
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We evaluate two novel applications for browsing personal collections of geo-referenced digital photographs. The first, PhotoCompas, is a browser that employs no graphical user interface elements other than the photos themselves (textual browser). PhotoCompas was developed in our project, and is based on an automated organization of the respective photo collection into clustered locations and ev...
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ژورنال
عنوان ژورنال: ACM SIGPLAN Notices
سال: 2006
ISSN: 0362-1340,1558-1160
DOI: 10.1145/1111320.1111053